15
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T13259 | URAT1 inhibitor 1 | OAT | |
URAT1 inhibitor 1 (1g) is an inhibitor of uric acid transporter 1 (URAT1) (IC50: 32 nM), has the potential to treat hyperuricemia associated with gout. | |||
T3994 | Verinurad | RDEA3170 | OAT |
Verinurad (RDEA3170) (RDEA3170) is an organic anion transporter URAT1 (SLC22A12) inhibitor for the treatment of gout and hyperuricemia. | |||
T79175 | URAT1&XO inhibitor 1 | Xanthine Oxidase | |
URAT1&XO Inhibitor 1 (compound 29) serves as a dual inhibitor with IC50 values of approximately 10 μM for URAT1 and 1.01 μM for Xanthine Oxidase. It induces a hypouricemic effect in the potassium oxonate-induced hyperuri... | |||
T20545 | Benzarone | Benzarona,Vasoc,Venagil,Benzaronum | OAT |
Benzarone (Benzarona) is a potent inhibitor of human uric acid transporter 1 (URAT1, IC50 = 2.8 μM in oocyte). Benzarone lowers the level of uric acid serum. | |||
T6875 | Lesinurad | RDEA594 | OAT |
Lesinurad (RDEA594) is a selective inhibitor of uric acid reabsorption which is used in combination with other agents in the therapy of gout. Lesinurad has had a limited clinical use but has not been associated with seru... | |||
T15160 | Dotinurad | (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone | OAT |
Dotinurad ((3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone) is a potent agent of uricosuric (IC50: 3.6 μM for uric acid). | |||
T60724 | URAT1 inhibitor 3 | ||
URAT1 inhibitor 3 is a potent, orally active, selective inhibitor of URAT1(IC 50 = 0.8 nM). URAT1 inhibitor 3 shows urate-lowering efficacy that can be used in gout and hyperuricemi research [1]. | |||
T72632 | URAT1 inhibitor 4 | ||
URAT1 Inhibitor 4, derived from Lesinurad, is a potent, orally active inhibitor of URAT1 with an IC50 value of 7.56 μM, demonstrating greater in vivo urate-lowering efficacy than Lesinurad [1]. | |||
T79114 | URAT1 inhibitor 5 | ||
URAT1 Inhibitor 5 (compound 16) serves as a powerful inhibitor of URAT1 and is utilized in hyperuricemia research [1]. | |||
T27697 | JTT-552 | ||
JTT-552, a uric acid transporter 1 (URAT1) inhibitor, is used potentially for the treatment of hyperuricemia. | |||
T78195 | URAT1 inhibitor 8 | ||
URAT1 Inhibitor 8 (example 247) serves as a highly potent inhibitor of URAT1, demonstrating an IC50 value of 0.001 μM. It is applicable in the study of gout [1]. | |||
T79176 | URAT1 inhibitor 6 | ||
URAT1 inhibitor 6 (Compound 1h), with an IC50 of 35 nM for hURAT1, demonstrates 200-fold and 8-fold greater potency compared to Lesinurad and Benzbromarone, respectively. This compound is utilized in the study of inflamm... | |||
T62432 | KPH2f | ||
KPH2f, a dual URAT1/GLUT9 inhibitor, demonstrates safety, oral activity, and efficacy, with inhibitory concentrations (IC50s) of 0.24 μM for URAT1 and 9.37 μM for GLUT9. It exhibits minimal effects on OAT1 and ABCG2, wit... | |||
T79177 | URAT1&XO inhibitor 2 | Xanthine Oxidase | |
Compound BDEO (URAT1&XO inhibitor 2) serves as a dual-action inhibitor targeting both xanthine oxidase (XO) and URAT1, demonstrating an IC50 value of 3.3 μM for XO inhibition. It effectively impedes uric acid uptake in H... | |||
T27275 | Epaminurad | ||
Epaminurad (UR-1102) is an orally active, potent and selective URAT1 (urate transporter 1) inhibitor, with a Ki of 0.057 μM. Epaminurad inhibits OAT1 and OAT3 (organic anion transporter) quite modestly. Epaminurad is a u... |